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Food and Drugs

Food and Drugs Importance of making time

This is an important aspect of the administration of oral medications. Restrictions on the medication in relation to meals based on two principles:

Ensuring Efficiency:

The meal can influence the pharmacokinetics of drugs. The amendments are multiple (absorption rate, peak serum, gastric emptying, metabolism) and may be accompanied by a change in bioavailability. Any changes in bioavailability may influence drug efficacy.

Improve the digestive tolerance:

Taking definite medications with meals designed to improve gastrointestinal tolerance. This is particularly true for anti-inflammatory agents, certain antibiotics, etc.... On the other hand, some drugs that act in the gastrointestinal tract are the subject of specific recommendations regarding their decision or not with a meal (e.g., antacids, digestive enzymes, antifungal ...)

Examples of drugs whose absorption is modified by intestinal food

Reduced absorption

  • Penincilline, tetracyclines (if simultaneous absorption of dairy products)
  • Acetylsalicylic acid
  • Levodopa
  • Theophylline (if simultaneous absorption of protein)
  • Sotalol

Delayed absorption

  • Cephalosporins (if simultaneous absorption of dairy products)
  • Erythromycin
  • Sulfonamides
  • Furosemide
  • Cimetidine
  • Digoxin (if absorption of too much fiber)
  • Ibuprofen

Increased absorption

  • Griseofulvin (if simultaneous absorption of fat)
  • Nitrofurans (however diminished if taken on an empty stomach)
  • Diazepam
  • Hydrochlorothiazide
  • Lithium (however diminished if taken on an empty stomach)
  • Propranolol (a reduction of the effect of first pass metabolism)
  • Metoprolol
  • Phenytoin (through enzyme induction)